Engineering Stem Cell Self-organization to Build Better Organoids

Organoids form through self-organization processes in which initially homogeneous populations of stem cells spontaneously break symmetry and undergo in-vivo-like pattern formation and morphogenesis, though the processes controlling this are poorly characterized. While these in vitro self-organized tissues far exceed the microscopic and functional complexity obtained by current tissue engineering technologies, they are non-physiological in shape and size and have limited function and lifespan. Here, we discuss how engineering efforts for guiding stem-cell-based development at multiple stages can form the basis for the assembly of highly complex and rationally designed self-organizing multicellular systems with increased robustness and physiological relevance.


Published in:
Cell Stem Cell, 24, 6, 860-876
Year:
Jun 06 2019
Publisher:
Cambridge, CELL PRESS
ISSN:
1934-5909
1875-9777
Keywords:
Laboratories:




 Record created 2019-06-19, last modified 2019-08-30


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