Allostery in Its Many Disguises: From Theory to Applications

Allosteric regulation plays an important role in many biological processes, such as signal transduction, transcriptional regulation, andmetabolism. Allostery is rooted in the fundamental physical properties of macromolecular systems, but its underlying mechanisms are still poorly understood. A collection of contributions to a recent interdisciplinary CECAM(Center Europeen de Calcul Atomique et Moleculaire) workshop is used here to provide an overview of the progress and remaining limitations in the understanding of the mechanistic foundations of allostery gained from computational and experimental analyses of real protein systems and model systems. The main conceptual frameworks instrumental in driving the field are discussed. We illustrate the role of these frameworks in illuminating molecular mechanisms and explaining cellular processes, and describe some of their promising practical applications in engineering molecular sensors and informing drug design efforts.


Published in:
Structure, 27, 4, 566-578
Year:
Apr 02 2019
Publisher:
Cambridge, CELL PRESS
ISSN:
0969-2126
1878-4186
Keywords:
Laboratories:




 Record created 2019-06-18, last modified 2019-08-06


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