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  4. Effect of Fc Receptor Genetic Diversity on HIV-1 Disease Pathogenesis
 
review article

Effect of Fc Receptor Genetic Diversity on HIV-1 Disease Pathogenesis

Geraghty, Daniel E.
•
Thorball, Christian W.  
•
Fellay, Jacques  
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May 9, 2019
Frontiers In Immunology

Fc receptor (FcR) genes collectively have copy number and allelic polymorphisms that have been implicated in multiple inflammatory and autoimmune diseases. This variation might also be involved in etiology of infectious diseases. The protective role of Fc-mediated antibody-function in HIV-1 immunity has led to the investigation of specific polymorphisms in FcR genes on acquisition, disease progression, and vaccine efficacy in natural history cohorts. The purpose of this review is not only to explore these known HIV-1 host genetic associations, but also to re-evaluate them in the context of genome-wide data. In the current era of effective anti-retroviral therapy, the potential impact of such variation on post-treatment cohorts cannot go unheeded and is discussed here in the light of current findings. Specific polymorphisms associating with HIV-1 pathogenesis have previously been genotyped by assays that captured only the single-nucleotide polymorphism (SNP) of interest without relative information of neighboring variants. With recent technological advances, variation within these genes can now be characterized using next-generation sequencing, allowing precise annotation of the whole chromosomal region. We herein also discuss updates in the annotation of common FcR variants that have been previously associated with HIV-1 pathogenesis.

  • Details
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Type
review article
DOI
10.3389/fimmu.2019.00970
Web of Science ID

WOS:000467436800001

Author(s)
Geraghty, Daniel E.
Thorball, Christian W.  
Fellay, Jacques  
Thomas, Rasmi
Date Issued

2019-05-09

Published in
Frontiers In Immunology
Volume

10

Start page

970

Subjects

Immunology

•

next-generation sequencing

•

polymorphism

•

disease association

•

fc receptors

•

hiv-1

•

copy number variation

•

human-igg

•

protective efficacy

•

polymorphic forms

•

vaccine efficacy

•

infection

•

expression

•

affinity

•

variants

•

cells

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
UPFELLAY  
Available on Infoscience
June 18, 2019
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/157962
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