Differential regulation of RNA polymerase III genes during liver regeneration

Mouse liver regeneration after partial hepatectomy involves cells in the remaining tissue synchronously entering the cell division cycle. We have used this system and H3K4me3, Pol II and Pol III profiling to characterize adaptations in Pol III transcription. Our results broadly define a class of genes close to H3K4me3 and Pol II peaks, whose Pol III occupancy is high and stable, and another class, distant from Pol II peaks, whose Pol III occupancy strongly increases after partial hepatectomy. Pol III regulation in the liver thus entails both highly expressed housekeeping genes and genes whose expression can adapt to increased demand.


Published in:
Nucleic Acids Research, 47, 4, 1786-1796
Year:
Feb 28 2019
Publisher:
Oxford, Oxford University Press (OUP)
ISSN:
0305-1048
Keywords:
Note:
This article is licensed under a Creative Commons Attribution 4.0 International License
Laboratories:


Note: The status of this file is: Anyone


 Record created 2019-06-18, last modified 2020-05-19

Final:
Download fulltext
PDF

Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)