New Binding Sites, New Opportunities for GPCR Drug Discovery

Many central biological events rely on protein-ligand interactions. The identification and characterization of protein-binding sites for ligands are crucial for the understanding of functions of both endogenous ligands and synthetic drug molecules. G protein-coupled receptors (GPCRs) typically detect extracellular signal molecules on the cell surface and transfer these chemical signals across the membrane, inducing downstream cellular responses via G proteins or beta-arrestin. GPCRs mediate many central physiological processes, making them important targets for modern drug discovery. Here, we focus on the most recent breakthroughs in finding new binding sites and binding modes of GPCRs and their potentials for the development of new medicines.


Published in:
Trends In Biochemical Sciences, 44, 4, 312-330
Year:
Apr 01 2019
Publisher:
London, ELSEVIER SCIENCE LONDON
ISSN:
0968-0004
1362-4326
Keywords:
Laboratories:




 Record created 2019-06-18, last modified 2019-07-17


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