Repository logo

Infoscience

  • English
  • French
Log In
Logo EPFL, École polytechnique fédérale de Lausanne

Infoscience

  • English
  • French
Log In
  1. Home
  2. Academic and Research Output
  3. Journal articles
  4. IL-4R alpha-Expressing B Cells Are Required for CXCL13 Production by Fibroblastic Reticular Cells
 
research article

IL-4R alpha-Expressing B Cells Are Required for CXCL13 Production by Fibroblastic Reticular Cells

Dubey, Lalit Kumar  
•
Ludewig, Burkhard
•
Luther, Sanjiv A.
Show more
May 21, 2019
Cell Reports

Adaptive type 2 immune responses against the intestinal helminth Heligmosomoides polygyrus (Hp) require the interaction of follicle-associated CXCR5(+) dendritic cells with naive T cells in the draining mesenteric lymph nodes (mLNs). However, the source of CXCL13 responsible for attracting CXCR5(+) dendritic cells has remained unclear. Using multiplex imaging combined with deep tissue analysis, we observed new CXCL13(+) fibroblastic reticular cells surrounding paracortical and cortical B cell follicles in the mLNs of infected mice. CXCL13(+) fibroblasts expressed markers of marginal reticular cells (MRCs), and their expansion required lymphotoxin (LT)-dependent interactions between IL-4R alpha-expressing B cells and CCL19(+) fibroblasts. Infection-induced follicles did not necessarily contain follicular dendritic cells (FDCs), indicating that CXCL13(+) fibroblasts may instead drive their formation. These data reveal a role for lymphotoxin signaling to CCL19(+) fibroblasts in the development of CXCL13(+) MRC-like cells and adaptive type 2 immunity in response to helminth infection.

  • Files
  • Details
  • Metrics
Loading...
Thumbnail Image
Name

1-s2.0-S2211124719305595-main.pdf

Type

Publisher's Version

Version

http://purl.org/coar/version/c_970fb48d4fbd8a85

Access type

openaccess

License Condition

CC BY-NC-ND

Size

16.37 MB

Format

Adobe PDF

Checksum (MD5)

a43e890e6e2e08763682f8f42769dcbe

Logo EPFL, École polytechnique fédérale de Lausanne
  • Contact
  • infoscience@epfl.ch

  • Follow us on Facebook
  • Follow us on Instagram
  • Follow us on LinkedIn
  • Follow us on X
  • Follow us on Youtube
AccessibilityLegal noticePrivacy policyCookie settingsEnd User AgreementGet helpFeedback

Infoscience is a service managed and provided by the Library and IT Services of EPFL. © EPFL, tous droits réservés