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  4. A method for improvement of mass resolution and isotope accuracy for laser ablation time-of-flight mass spectrometers
 
research article

A method for improvement of mass resolution and isotope accuracy for laser ablation time-of-flight mass spectrometers

Wiesendanger, Reto  
•
Tulej, Marek
•
Grimaudo, Valentine
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January 1, 2019
Journal Of Chemometrics

Accumulation of spectra is a common approach for improvement of the signal-to-noise ratio (SNR) in mass spectrometry. However, severe degradation of the overall spectrum can occur if some individual mass spectra, affected by peak broadening, are included in the accumulation process. In this contribution, we discuss potential sources and effects of spectral distortions by using examples from mass spectra acquired by our miniature laser ablation/ionisation time-of-flight mass spectrometer. We show how recent developments in acquisition systems enable to identify individual spectra subjected to peak broadening and present a filtering method capable of systematic and reproducible exclusion of such spectra from the accumulation process. We show that the method can be used on a wide range of materials and present a detailed case study performed on a trevorite mineral sample. Using this method, improvements of the isotope accuracy of Si, Ni, and Cr by factors between 1.6 and 7.7 were achieved. Finally, we discuss the limitations of the method and provide complementary analysis of other materials in the supplementary documents provided with this contribution.

  • Details
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Type
research article
DOI
10.1002/cem.3081
Web of Science ID

WOS:000456061000004

Author(s)
Wiesendanger, Reto  
Tulej, Marek
Grimaudo, Valentine
Cedeno-Lopez, Alena
Lukmanov, Rustam
Riedo, Andreas
Wurz, Peter
Date Issued

2019-01-01

Publisher

WILEY

Published in
Journal Of Chemometrics
Volume

33

Issue

1

Article Number

e3081

Subjects

Automation & Control Systems

•

Chemistry, Analytical

•

Computer Science, Artificial Intelligence

•

Instruments & Instrumentation

•

Mathematics, Interdisciplinary Applications

•

Statistics & Probability

•

Chemistry

•

Computer Science

•

Mathematics

•

filtering method

•

improvement of quantitative performance

•

isotope accuracy

•

laser ablation and ionisation time-of-flight mass spectrometry (lims-tof)

•

mass resolution

•

ionization

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

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Available on Infoscience
June 18, 2019
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/157429
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