Manganese-mediated reductive amidation of esters with nitroarenes

Amides are ubiquitous molecules in nature and in synthetic chemistry. Here we report a convenient and efficient method to synthesize N-aryl amides via amidation of esters with nitroarenes. In the presence of manganese metal, this amidation proceeded smoothly without the need for additional catalysts or ligands. Various esters and nitroarenes are suitable substrates to afford a wide range of N-aryl amides, including bio-active molecules and intermediates to drug molecules.


Published in:
Organic Chemistry Frontiers, 6, 6, 756-761
Year:
Mar 21 2019
Publisher:
Cambridge, ROYAL SOC CHEMISTRY
ISSN:
2052-4129
Keywords:
Laboratories:




 Record created 2019-06-18, last modified 2019-06-26


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