Metasurfaceābased molecular biosensing aided by artificial intelligence
Molecular spectroscopy provides unique information on the internal structure of biological materials by detecting the characteristic vibrational signatures of their constituent chemical bonds at infrared frequencies. Nanophotonic antennas and metasurfaces have driven this concept towards fewāmolecule sensitivities by confining incident light into intense hot spots of the electromagnetic fields, providing strongly enhanced lightāmatter interaction. In this Minireview, recently developed molecular biosensing approaches based on the combination of dielectric metasurfaces and imaging detection are highlighted in comparison to traditional plasmonic geometries, and the unique potential of artificial intelligence techniques for nanophotonic sensor design and data analysis is emphasized. Because of their spectrometerāless operation principle, such imagingābased approaches hold great promise for miniaturized biosensors in practical pointāofācare or fieldādeployable applications.
2019-04-25
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