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research article
Formal [4+1] Cycloaddition of o ‐Aminobenzyl Chlorides with Isocyanides: Synthesis of 2‐Amino‐3‐Substituted Indoles
Reaction of substituted o-aminobenzyl chlorides with isocyanides in the presence of a weak base (NaHCO3) at room temperature afforded the diversely functionalized 2-aminoindoles in good to excellent yields. A formal [4+1] cycloaddition of the in situ generated aza-ortho-xylylenes with isocyanides accounted for the reaction outcome.
Type
research article
Authors
Jong, Jacobus A. W.
•
Bao, Xu
•
Wang, Qian
•
Zhu, Jieping
Publication date
2019
Published in
Volume
102
Issue
3
Article Number
e1900002
Peer reviewed
REVIEWED
EPFL units
Funder | Grant Number |
FNS | FNS |
Available on Infoscience
May 3, 2019
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