Formal [4+1] Cycloaddition of o ‐Aminobenzyl Chlorides with Isocyanides: Synthesis of 2‐Amino‐3‐Substituted Indoles
Jong, Jacobus A. W.; Bao, Xu; Wang, Qian; Zhu, Jieping
2019

Abstract

Reaction of substituted o-aminobenzyl chlorides with isocyanides in the presence of a weak base (NaHCO3) at room temperature afforded the diversely functionalized 2-aminoindoles in good to excellent yields. A formal [4+1] cycloaddition of the in situ generated aza-ortho-xylylenes with isocyanides accounted for the reaction outcome.

Details

Title Formal [4+1] Cycloaddition of o ‐Aminobenzyl Chlorides with Isocyanides: Synthesis of 2‐Amino‐3‐Substituted Indoles
Author(s) Jong, Jacobus A. W. ; Bao, Xu ; Wang, Qian ; Zhu, Jieping
Published in Helvetica Chimica Acta
Volume 102
Issue 3
Pages e1900002
Date 2019
Keywords
DOI https://doi.org/10.1002/hlca.201900002
Other identifier(s) DOI: https://doi.org/10.1002/hlca.201900002
Laboratories LSPN
Record Appears in Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LSPN - Laboratory of synthesis and natural products
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Grant FNS: FNS
Record creation date 2019-05-03