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  4. The functional role of beta‐oscillations in the supplementary motor area during reaching and grasping after stroke: A question of structural damage to the corticospinal tract
 
research article

The functional role of beta‐oscillations in the supplementary motor area during reaching and grasping after stroke: A question of structural damage to the corticospinal tract

Quandt, Fanny
•
Bönstrup, Marlene
•
Schulz, Robert
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March 29, 2019
Human Brain Mapping

Hand motor function is often severely affected in stroke patients. Non-satisfying recovery limits reintegration into normal daily life. Understanding stroke-related network changes and identifying common principles that might underlie recovered motor function is a prerequisite for the development of interventional therapies to support recovery. Here, we combine the evaluation of functional activity (multichannel electroencephalography) and structural integrity (diffusion tensor imaging) in order to explain the degree of residual motor function in chronic stroke patients. By recording neural activity during a reaching and grasping task that mimics activities of daily living, the study focuses on deficit-related neural activation patterns. The study showed that the functional role of movement-related beta desynchronization in the supplementary motor area (SMA) for residual hand motor function in stroke patients depends on the microstructural integrity of the corticospinal tract (CST). In particular, in patients with damaged CST, stronger task-related activity in the SMA was associated with worse residual motor function. Neither CST damage nor functional brain activity alone sufficiently explained residual hand motor function. The findings suggest a central role of the SMA in the motor network during reaching and grasping in stroke patients, the degree of functional relevance of the SMA is depending on CST integrity.

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Type
research article
DOI
10.1002/hbm.24582
Author(s)
Quandt, Fanny
Bönstrup, Marlene
Schulz, Robert
Timmermann, Jan E.
Mund, Maike
Wessel, Maximilian J.
Hummel, Friedhelm C.
Date Issued

2019-03-29

Published in
Human Brain Mapping
Volume

40

Issue

10

Start page

3091

End page

3101

Subjects

DTI

•

EEG

•

SMA

•

functional and structural neuroimaging

•

motor function

•

stroke recovery

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
UPHUMMEL  
FunderGrant Number

Other foundations

Deutsche Forschungsgemeinschaft, Grant/Award Number: SFB936‐C4 (to F.C.H)

Swiss foundations

Defitech Foundation

Other government funding

German National Academy of Sciences Leopoldina, Grant/Award Number: LPDS 2016‐01, to M.B.

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Available on Infoscience
April 25, 2019
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/156125
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