Cryogenic Ion Spectroscopy for Identification of Monosaccharide Anomers

We combine conformer-selective, cryogenic infrared spectroscopy, quantum mechanical computations, and 18O substitution at the reducing end to determine the structural preferences of protonated glucosamine in the gas phase. Cryogenic infrared-infrared (IR-IR) double resonance spectroscopy of helium-tagged protonated glucosamine provides vibrational fingerprints of individual conformers, and 18O isotopic labeling facilitates the match with computed structures and provides a selective probe of the anomeric hydroxyl. This is key for using vibrational spectroscopy for glycan analysis and determining the generality of anomeric memory during glycosidic bond cleavage.


Published in:
The Journal of Physical Chemistry, 123, 2815-2819
Year:
2019
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 Record created 2019-03-13, last modified 2020-04-20

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