Immuno-affinity Amperometric Detection of Bacterial Infections

A combination of an immuno-affinity enrichment strategy and sensitive amperometric read-out was implemented in a point-of-care platform intended for bacterial infection analysis. Bacterial cells, selectively captured and enriched from complex matrices through immuno-affinity, were detected by amperometric monitoring of the redox state of metabolic activity indicators, providing species identification and viable-cell quantification. The method was successfully employed for the diagnosis of bacterial infections including antimicrobial susceptibility testing with only several hours of total working time.


Published in:
Angewandte Chemie-International Edition, 57, 45, 14942-14946
Year:
Nov 05 2018
Publisher:
Weinheim, WILEY-V C H VERLAG GMBH
ISSN:
1433-7851
1521-3773
Keywords:




 Record created 2018-12-20, last modified 2019-06-19


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