Repository logo

Infoscience

  • English
  • French
Log In
Logo EPFL, École polytechnique fédérale de Lausanne

Infoscience

  • English
  • French
Log In
  1. Home
  2. Academic and Research Output
  3. Journal articles
  4. Cyclodextrin Modulated Type I Collagen Self-Assembly to Engineer Biomimetic Cornea Implants
 
research article

Cyclodextrin Modulated Type I Collagen Self-Assembly to Engineer Biomimetic Cornea Implants

Majumdar, Shoumyo
•
Wang, Xiaokun
•
Sommerfeld, Sven D.
Show more
October 10, 2018
Advanced Functional Materials

Collagen-rich tissues in the cornea exhibit unique and highly organized extracellular matrix ultrastructures, which contribute to its high load-bearing capacity and light transmittance. Corneal collagen fibrils are controlled during development by small leucine-rich proteoglycans (SLRPs) that regulate the fibril diameter and spacing in order to achieve the unique optical transparency. Cyclodextrins (CDs) of varying size and chemical functionality for their ability to regulate collagen assembly during vitrification process are screened in order to create biosynthetic materials that mimic the native cornea structure. Addition of beta CD to collagen vitrigels produces materials with aligned fibers and lamellae similar to native cornea, resulting in mechanically robust and transparent materials. Biochemistry analysis revealed that CD interacts with hydrophobic amino acids in collagen to influence assembly and fibril organization. To translate the self-assembled collagen materials for cornea reconstruction, custom molds for gelation and vitrification are engineered to create beta CD/Col implants with curvature matching that of the cornea. Acellular beta CD/Col materials are implanted in a rabbit partial keratoplasty model with interrupted sutures. The implants demonstrate tissue integration and support re-epithelialization. Therefore, the addition of CD molecules regulates collagen self-assembly and provides a simple process to engineer corneal mimetic substitutes with advanced structural and functional properties.

  • Details
  • Metrics
Type
research article
DOI
10.1002/adfm.201804076
Web of Science ID

WOS:000446550700016

Author(s)
Majumdar, Shoumyo
Wang, Xiaokun
Sommerfeld, Sven D.
Chae, Jemin Jeremy
Athanasopoulou, Evangelia-Nefeli  
Shores, Lucas S.
Duan, Xiaodong
Amzel, L. Mario
Stellacci, Francesco  
Schein, Oliver
Show more
Date Issued

2018-10-10

Publisher

WILEY-V C H VERLAG GMBH

Published in
Advanced Functional Materials
Volume

28

Issue

41

Article Number

1804076

Subjects

Chemistry, Multidisciplinary

•

Chemistry, Physical

•

Nanoscience & Nanotechnology

•

Materials Science, Multidisciplinary

•

Physics, Applied

•

Physics, Condensed Matter

•

Chemistry

•

Science & Technology - Other Topics

•

Materials Science

•

Physics

•

collagen

•

cornea

•

cyclodextrins

•

fibril alignment

•

self-assembly

•

beta-cyclodextrin

•

vitrigel membranes

•

protein

•

regeneration

•

architecture

•

epithelium

•

hydrogels

•

stroma

•

ultrastructure

•

nanoparticles

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
SUNMIL  
Available on Infoscience
December 13, 2018
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/152725
Logo EPFL, École polytechnique fédérale de Lausanne
  • Contact
  • infoscience@epfl.ch

  • Follow us on Facebook
  • Follow us on Instagram
  • Follow us on LinkedIn
  • Follow us on X
  • Follow us on Youtube
AccessibilityLegal noticePrivacy policyCookie settingsEnd User AgreementGet helpFeedback

Infoscience is a service managed and provided by the Library and IT Services of EPFL. © EPFL, tous droits réservés