Impact of MCT1 Haploinsufficiency on the Mouse Retina
Peachey, Neal S.; Yu, Minzhong; Han, John Y. S.; Lengacher, Sylvain; Magistretti, Pierre J.; Pellerin, Luc; Philp, Nancy J.
2018

Abstract

The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1+/- heterozygotes, which express half of the normal complement of MCT1. The MCT1(+/-) retina developed normally and retained normal function, indicating that MCT1 is expressed at sufficient levels to support outer retinal metabolism.

Details

Title Impact of MCT1 Haploinsufficiency on the Mouse Retina
Author(s) Peachey, Neal S. ; Yu, Minzhong ; Han, John Y. S. ; Lengacher, Sylvain ; Magistretti, Pierre J. ; Pellerin, Luc ; Philp, Nancy J.
Published in Retinal Degenerative Diseases: Mechanisms And Experimental Therapy
Series Advances in Experimental Medicine and Biology, 1074
Pages 375-380
Conference 17th International Symposium on Retinal Degeneration (RD), Sep 19-24, 2016, Kyoto, JAPAN
Date 2018-01-01
Publisher Cham, SPRINGER INTERNATIONAL PUBLISHING AG
ISSN 0065-2598
2214-8019
ISBN 978-3-319-75402-4
978-3-319-75401-7
Keywords
DOI https://doi.org/10.1007/978-3-319-75402-4_46
Other identifier(s) View record in Web of Science
Laboratories LNDC
Record Appears in Peer-reviewed publications
Conference Papers
Work produced at EPFL
Published
Record creation date 2018-12-13