Waste heat recovery from passenger car internal combustion engines by means of an organic Rankine cycle (ORC) system is promising for reducing CO2 emissions. In this study, different cycle configurations capable of converting waste heat from both coolant and exhaust gases are investigated based on different working fluid categories. Radial-inflow turbines are considered as expansion devices and corresponding isentropic efficiencies are evaluated based on a preliminary design map accounting for the effect of the pressure ratio. Mechanical losses resulting from the use of a gas-bearing-supported rotor driving a permanent magnet generator are also evaluated. In order to identify the turbo-ORC system design tradeoffs, constrained multi-variable and multi-objective optimizations are performed using an evolutionary algorithm. It is found that the optimal cycle configuration and working fluid depend on the available space in the vehicle and that the condenser is the most critical component for the ORC system integration. In addition, the most suitable working fluids for this application are characterized by (1) a boiling point close to the heat sink temperature, (2) a high critical pressure, and (3) a high molecular weight. The resulting optimal radial-inflow turbines are 10e33 mm in tip diameter and operate at 80 e330 krpm.