Repository logo

Infoscience

  • English
  • French
Log In
Logo EPFL, École polytechnique fédérale de Lausanne

Infoscience

  • English
  • French
Log In
  1. Home
  2. Academic and Research Output
  3. Journal articles
  4. Applying a Trojan Horse Strategy to Ruthenium Complexes in the Pursuit of Novel Antibacterial Agents
 
research article

Applying a Trojan Horse Strategy to Ruthenium Complexes in the Pursuit of Novel Antibacterial Agents

Laurent, Quentin
•
Batchelor, Lucinda K.
•
Dyson, Paul J.
2018
Organometallics

Siderophores are iron chelators secreted by bacteria to scavenge iron(III) from their surrounding environment. They possess their own internalization pathway that is sufficiently unselective to be hijacked, making them suitable for Trojan Horse strategy applications. A commercially available siderophore, deferoxamine B (DFO), was derivatized at the primary amine with carboxylic acids bearing different ligands to afford mono- and bidentate complexes with ruthenium as well as a RAPTA-like complex in which DFO is tethered to the coordinated arene ring. These compounds were tested for antibacterial activity against key ESKAPE pathogens, and antiproliferative studies against healthy (HEK-293) and tumoral (A2780) human cells were performed. Some of the complexes displayed interesting dual anticancer and antibacterial properties. Combining these two properties within a single compound is desirable as patients treated for cancer have a weakened ability for fighting infections.

  • Files
  • Details
  • Metrics
Loading...
Thumbnail Image
Name

Applying a Trojan Horse Strategy to Ruthenium Complexes in the Pursuit of Novel Antibacterial Agents.pdf

Type

Publisher's Version

Version

http://purl.org/coar/version/c_970fb48d4fbd8a85

Access type

openaccess

Size

953.55 KB

Format

Adobe PDF

Checksum (MD5)

e30bf984101e902add2a43cc319943b3

Logo EPFL, École polytechnique fédérale de Lausanne
  • Contact
  • infoscience@epfl.ch

  • Follow us on Facebook
  • Follow us on Instagram
  • Follow us on LinkedIn
  • Follow us on X
  • Follow us on Youtube
AccessibilityLegal noticePrivacy policyCookie settingsEnd User AgreementGet helpFeedback

Infoscience is a service managed and provided by the Library and IT Services of EPFL. © EPFL, tous droits réservés