Suspended Microchannel Resonators (SMRs) enable real time analysis of fluidic samples with almost no degradation of the quality factor. - Energy dissipation is a non-monotonic function of the fluid viscosity. - Quality factor is highly dependent on the microfluidic channel placement with respect to the beam neutral axis. - Experimental study of the effect of the channel off-axis placement on the device’s quality factor. - Fabrication of SMRs with six different values of channel off-axis placement.