Reducing sensing time is one major concern in clinical diagnostics. In the present work, a robust measurement system is developed aiming at the faster and easier signal acquisition of memristive biosensors. Sensing chips consisting of nanofabricated silicon wires exhibiting memristive electrical response and metallic extension electrodes allowing an integrated measurement procedure are designed and fabricated. Furthermore, the electrical response of these particular nanofabricated structures is for the first time acquired using an embedded-system-based measurement front-end. The suggested prototype significantly simplifies the measurement procedure and provides conveniently the response signal of the devices. Such optimized co-design of memristive biosensors with electronic platforms hold great promise for PoC (point-of-care) applications.