Versatile palladium-catalyzed double carbonylation of aryl bromides

A versatile palladium-catalyzed double carbonylation of aryl bromides has been developed. Using Pd(OAc)2/BuPAd2 as the catalyst system and DBU as the base, under relatively low CO pressure, various a-ketoamides were produced in good yields. In order to get insight into the reaction pathway, real time NMR studies were performed as well and a correlated reaction mechanism is been given.


Published in:
Chem. Commun., 53, 12422-12425
Year:
2017
ISSN:
1364-548X
Laboratories:




 Record created 2017-11-11, last modified 2018-09-13


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