Centriole Biogenesis: From Identifying the Characters to Understanding the Plot

The centriole is a beautiful microtubule-based organelle that is critical for the proper execution of many fundamental cellular processes, including polarity, motility, and division. Centriole biogenesis, the making of this miniature architectural wonder, has emerged as an exemplary model to dissect the mechanisms governing the assembly of a eukaryotic organelle. Centriole biogenesis relies on a set of core proteins whose contributions to the assembly process have begun to be elucidated. Here, we review current knowledge regarding the mechanisms by which these core characters function in an orderly fashion to assemble the centriole. In particular, we discuss how having the correct proteins at the right place and at the right time is critical to first scaffold, then initiate, and finally execute the centriole assembly process, thus underscoring fundamental principles governing organelle biogenesis.


Editor(s):
Schekman, R
Published in:
Annual Review Of Cell And Developmental Biology, Vol 33, 33, 23-49
Year:
2017
Publisher:
Palo Alto, Annual Reviews
ISSN:
1081-0706
ISBN:
978-0-8243-3133-7
Keywords:
Laboratories:




 Record created 2017-11-08, last modified 2019-04-15


Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)