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research article
Enantioselective C-H Functionalization-Addition Sequence Delivers Densely Substituted 3-Azabicyclo[3.1.0]hexanes
An enantioselective C-H functioffalization route to perfluoroalkyl-containing 3-azabicyclo[3.1.0]-hexanes is disclosed. A modular and bench-stable diazaphospholane ligand enables highly enantioselective Pd(0)-catalyzed cyclopropane C-H functionalization using trifluoroacetimidoyl chlorides as electrophilic partners. In turn, the resulting cyclic ketimine products react smoothly with a broad variety of nudeophiles in one-pot processes enabling the rapid and modular construction of heavily substituted pyrrolidines.
Type
research article
Web of Science ID
WOS:000411043900017
Authors
Publication date
2017
Publisher
Published in
Volume
139
Issue
36
Start page
12398
End page
12401
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
October 9, 2017
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