Enhancers of notch signaling and their use in the treatment of cancers and malignancies medicable by upregulation of notch
The present invention relates to the use for enhancing Notch signaling in an individual, of a compound showing the general formula (I) and/or a pharmaceutically acceptable salt or ester thereof, for the treatment of a disease selected from the group of dermatological disorders including atopic dermatitis, psoriasis, immune related disorders, cancer, squamous cell carcinoma, cutaneous and lung squamous cell carcinoma, head and neck cancer, non-melanoma skin cancer, basal cell carcinoma and actinic keratosis, neuroendocrine tumors, neuroendocrine small cell carcinoma and carcinoid tumors, thyroid carcinomas, muscular disorders muscular dystrophy and impaired regeneration capacity after injury; use in immunotherapy for cancer.
55628769
Alternative title(s) : (de) Enhancer von notch-signalisierung und deren verwendung in der behandlung von durch hochregulierung von notch behandelbaren krebsen und malignomen (fr) Activateurs de signalisation notch et leur utilisation dans le traitement de cancers et de malignités guérissables par régulation à la hausse de notch
TTO:6.1502
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