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Francis turbines are subject to various types of the cavitation flow depending on the operating condition s. In order to compensate for the stochastic nature of renewable energy sources, it is more and more required to extend the operating range of the generating units, from deep part load to full load conditions. In the deep part load condition, the formation of cavitation vortices in the turbine blade-to-blade channel s called inter -blade cavitation vortex is often observed. The understanding of the dynamic characteristics of these inter -blade vortices and their formation mechanisms is of key importance in an effort of developing reliable flow simulation tools. This paper reports the numerical and experimental investigations carried out in order to establish the vortex characteristics, especially the inception and the development of the vortex structure. The unsteady RANS simulation for the multiphase flow is performed with the SST - SA S turbulence model by using the commercial flow solver ANSYS CFX. The simulation results in terms of the vortex structure and the cavitation volume are evaluated by comparing them to the flow visualization s of the blade channel acquired through a specially instrumented guide vane as well as from the downstream of the runner across the draft tube cone. The inter-blade cavitation vortex is successfully captured by the simulation and both numerical and experimental results evidence that the inter -blade vortices are attached to the runner hub.