Gold-Catalyzed Synthesis of 1,3-Diaminopyrazoles from 1-Alkynyltriazenes and Imines

A new procedure for the synthesis of highly substituted 1,3-diaminopyrazoles is described. As substrates, we have employed 1-alkynyltriazenes and imines. The formation of pyrazoles was achieved by two-fold C–N coupling reactions in the presence of (JohnPhos)AuCl and AgNTf2 as catalyst precursors. The regioselectivity of the reaction was inferred from a crystallographic analysis of one reaction product.


Published in:
Helvetica Chimica Acta, 100, e1700186
Year:
2017
Publisher:
Weinheim, Wiley-Blackwell
ISSN:
0018-019X
Keywords:
Laboratories:




 Record created 2017-09-27, last modified 2018-03-17


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