Role of SEC62 in ER maintenance: A link with ER stress tolerance in SEC62-overexpressing tumors?

Amplification of the candidate oncogene TLOC1/SEC62 in tumors correlates with reduced patient survival. The recently reported role of SEC62 as an autophagy receptor that controls endoplasmic reticulum (ER) size and function might open new scenarios for understanding the phenotypes and treat SEC62high tumors, which are characterized by high ER stress tolerance.


Published in:
Molecular & Cellular Oncology, 4, 2, e1264351
Year:
2017
Publisher:
Philadelphia, Taylor & Francis Inc
ISSN:
2372-3556
Keywords:
Laboratories:




 Record created 2017-09-05, last modified 2018-09-13


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