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  4. Mfn2 is critical for brown adipose tissue thermogenic function
 
research article

Mfn2 is critical for brown adipose tissue thermogenic function

Boutant, Marie
•
Kulkarni, Sameer S.
•
Joffraud, Magali
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2017
Embo Journal

Mitochondrial fusion and fission events, collectively known as mitochondrial dynamics, act as quality control mechanisms to ensure mitochondrial function and fine-tune cellular bioenergetics. Defective mitofusin 2 (Mfn2) expression and enhanced mitochondrial fission in skeletal muscle are hallmarks of insulin-resistant states. Interestingly, Mfn2 is highly expressed in brown adipose tissue (BAT), yet its role remains unexplored. Using adipose-specific Mfn2 knockout (Mfn2-adKO) mice, we demonstrate that Mfn2, but not Mfn1, deficiency in BAT leads to a profound BAT dysfunction, associated with impaired respiratory capacity and a blunted response to adrenergic stimuli. Importantly, Mfn2 directly interacts with perilipin 1, facilitating the interaction between the mitochondria and the lipid droplet in response to adrenergic stimulation. Surprisingly, Mfn2-adKO mice were protected from high-fat diet-induced insulin resistance and hepatic steatosis. Altogether, these results demonstrate that Mfn2 is a mediator of mitochondria to lipid droplet interactions, influencing lipolytic processes and whole-body energy homeostasis.

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Type
research article
DOI
10.15252/embj.201694914
Web of Science ID

WOS:000402532200008

Author(s)
Boutant, Marie
Kulkarni, Sameer S.
Joffraud, Magali
Ratajczak, Joanna
Valera-Alberni, Miriam
Combe, Roy
Zorzano, Antonio
Canto, Carles
Date Issued

2017

Publisher

Wiley

Published in
Embo Journal
Volume

36

Issue

11

Start page

1543

End page

1558

Subjects

brown adipose tissue

•

insulin resistance

•

lipid droplet

•

mitochondrial dynamics

•

mitofusin 2

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
SV  
Available on Infoscience
July 10, 2017
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/139043
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