A Longitudinal Study of Neurite Orientation Dispersion and Density Imaging in Relapsing-Remitting Multiple Sclerosis

We explored the sensitivity of a novel diffusion MRI method i.e. “Neurite orientation dispersion and density imaging”, to detect and characterize brain microstructure alterations in relapsing-remitting multiple sclerosis patients that we followed up over 2 years. Cross-sectionally, NODDI revealed that an increase in orientation dispersion and a decrease in neurite density in NAWM and in lesions of RRMS patients compared to healthy subjects. Longitudinally, NODDI measured a decreased dispersion and an increased neurite density in MS lesions at 2 years follow-up. Also, NODDI metrics at baseline were highly related to cognition at both baseline and follow-up.

Presented at:
25th Annual Meetinf of the International Society for Magnetic Resonance in Medicine, Honolulu, USA, April 22-27, 2017

 Record created 2017-06-22, last modified 2018-03-17

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