Materials and methods relating to encapsulation

Methods are provided for producing microcapsules based on two oppositely charged polymers, in particular to optimise the permeability and mechanical stability of microcapsules. The capsules are formed by introducing liquid droplets from an aqueous solution of a charged (usually anionic) polyelectrolyte (or a blend) into an aqueous solution of a counter-charged (usually cationic) polyelectrolyte (or a blend). The membrane is formed during the reaction time of the opposite-charged polymers. The capsules are optionally subject to an additional coating step.The methods are characterised by one or more of the following: the use of polyvinylamine (PVAm) of low Mw (<20kD); the use of a copolymer of PVAm (optionally of low Mw), especially poly-(vinyl alcohol)-co-vinylamine (PVA/PVAm); subjecting the droplets to a gelation step prior to contact with the counter-charged electrolyte, which comprises PMCG and/or a copolymer of PVAm; and/or simultaneously subjecting the droplets to a gelation step and contacting them with the counter-charged electrolyte, which comprises PVAm and/or a copolymer thereof.Capsules produced or producible according to these methods are also provided.


Year:
2001
Other identifiers:
EPO Family ID: 9891976
TTO: 6.0206
Laboratories:




 Record created 2017-06-13, last modified 2018-03-17


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