Fluorescent protein expressing cells with very high fluorescence are described as well as a method to obtain such cells. The fluorescence of such cells can be as high as about 1000 times the auto-fluorescence of the respective host cell. Due to the high fluorescence, said cells are very suitable tools in the development, surveillance and/or optimization of production processes, for selection of culture media and process parameters and for the determination of cell growth and the detection, quantification and monitoring of biomass.
22268622
Alternative title(s) : (de) Zellen, die mit einem optischen marker genetisch modifiziert sind (fr) Cellules genetiquement modifiees a l'aide d'un marqueur optique
TTO:6.0082
Patent number | Country code | Kind code | Date issued |
US6509174 | US | B2 | 2003-01-21 |
US2002058334 | US | A1 | 2002-05-16 |
EP1088058 | EP | A2 | 2001-04-04 |
WO9966032 | WO | A3 | 2000-04-20 |
AU4054399 | AU | A | 2000-01-05 |
WO9966032 | WO | A2 | 1999-12-23 |