Novel treatment for Alzheimer's disease
The present invention concerns a new pharmaceutical composition comprising an antagonist and a co-agonist of the N-methyl-D-aspartate-type glutamate receptor (NMDAR). The inventors found that the co-administration of these two compounds effectively inhibits production of amyloide-² peptide. In patient's suffering from Alzheimer's disease, these peptides are deposited in the extracellular matrix forming neuritic "plaques". Therefore, the present inventors identified a new possibility for prophylaxis and/or treatment of Alzheimer's disease by stopping the continued formation of neuropathological extracellular deposits.
39811696
Alternative title(s) : (de) Neue behandlung für morbus alzheimer (fr) Nouveau traitement pour la maladie d'alzheimer (en) Novel treatment for alzheimer's disease
TTO:6.0825
Patent number | Country code | Kind code | Date issued |
EP2111858 | EP | A1 | 2009-10-28 |