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review article

Application of imaging mass spectrometry approaches to facilitate metal-based anticancer drug research

Lee, Ronald F. S.
•
Theiner, Sarah
•
Meibom, Anders  
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2017
Metallomics

Mass spectrometry imaging is being increasingly used in metal-based anticancer drug development to study elemental and/or molecular drug distributions in different biological systems. The main analytical tools employed are SIMS (especially nanoSIMS), LA-ICP-MSI and MALDI-MSI as well as a combination of complementary imaging techniques. Main challenges are appropriate sample preparation methods, reliable and validated quantification strategies and a trade-off between sensitivity and spatial resolution. So far, research has mostly focused on the development of analytical methods for imaging with the long term goal to study drug uptake into tumor tissue and toxicity affected organs and to identify cellular targets of metal-based drugs. In this review we cover the technological features of the mass spectrometry imaging methods used and give an overview of the applications in metal-based anticancer drug research as well as some future perspectives.

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Type
review article
DOI
10.1039/c6mt00231e
Web of Science ID

WOS:000399771300004

Author(s)
Lee, Ronald F. S.
Theiner, Sarah
Meibom, Anders  
Koellensperger, Gunda
Keppler, Bernhard K.
Dyson, Paul J.  
Date Issued

2017

Publisher

Royal Society of Chemistry

Published in
Metallomics
Volume

9

Issue

4

Start page

365

End page

381

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LGB  
LCOM  
Available on Infoscience
May 30, 2017
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/138002
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