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research article

Computational approaches to developmental patterning

Morelli, L. G.
•
Uriu, K.
•
Ares, S.
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2012
Science

Computational approaches are breaking new ground in understanding how embryos form. Here, we discuss recent studies that couple precise measurements in the embryo with appropriately matched modeling and computational methods to investigate classic embryonic patterning strategies. We include signaling gradients, activator-inhibitor systems, and coupled oscillators, as well as emerging paradigms such as tissue deformation. Parallel progress in theory and experiment will play an increasingly central role in deciphering developmental patterning.

  • Details
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Type
research article
DOI
10.1126/science.1215478
Scopus ID

2-s2.0-84859633304

Author(s)
Morelli, L. G.
Uriu, K.
Ares, S.
Oates, A. C.  
Date Issued

2012

Publisher

American Association for the Advancement of Science

Published in
Science
Volume

336

Issue

6078

Start page

187

End page

191

Subjects

Biology

•

cell communication

•

cell differentiation

•

cell population

•

Cytology

•

embryo

•

embryo development

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Embryonic development

•

embryo pattern formation

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experimental study

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Gene expression

•

gene regulatory network

•

inhibitor

•

Measurement

•

morphogen

•

morphogenesis

•

nonhuman

•

Notch receptor

•

precision

•

priority journal

•

Review

•

signal transduction

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
UPOATES  
Available on Infoscience
May 30, 2017
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/137759
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