Computational approaches to developmental patterning

Computational approaches are breaking new ground in understanding how embryos form. Here, we discuss recent studies that couple precise measurements in the embryo with appropriately matched modeling and computational methods to investigate classic embryonic patterning strategies. We include signaling gradients, activator-inhibitor systems, and coupled oscillators, as well as emerging paradigms such as tissue deformation. Parallel progress in theory and experiment will play an increasingly central role in deciphering developmental patterning.


Published in:
Science, 336, 6078, 187-191
Year:
2012
ISSN:
00368075
Keywords:
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 Record created 2017-05-30, last modified 2018-03-17

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