4-Pyrimidinylamino-benzenesulfonamide derivatives and their use for the inhibition of polo-like kinase 1 (PLK1) for the treatment of cancer and their use for the treatment of bacterial infections
The present invention relates to 4-pyrimidinylamino-benzenesulfonamide derivatives of general formula (I) and pharmaceutically acceptable salts, solvates, hydrates, regioisomeric and polymorphic forms thereof, processes for manufacturing of them, the use of them, as well as pharmaceutical compositions containing at least one of them as pharmaceutically active agent(s) together with pharmaceutically acceptable carrier, excipient and/or diluents, especially for the inhibition of polo-like kinases (PLKs) and the treatment of cancer. Said 4-pyrimidinylamino-benzenesulfonamide compounds have been also identified as new drug candidates for the prevention and/or treatment of infectious diseases like bacterial diseases e.g. tuberculosis, including the currently multidrug-resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB) as well as for preventing tuberculosis.
50073225
Alternative title(s) : (de) 4-pyrimidinylamino-benzolsulfonamidderivate und deren verwendung zur hemmung von polo-like-kinase 1 (plk1) zur behandlung von krebs und deren verwendung zur behandlung von bakteriellen infektionen (fr) Dérivés de 4-pyrimidinylamino-benzènesulfonamide et leur utilisation dans l'inhibition de la plk1 (polo-like kinase 1) pour le traitement du cancer et leur utilisation dans le traitement de maladies infectieuses (en) 4-pyrimidinylamino-benzenesulfonamide derivatives and their use for the inhibition of polo-like kinase 1 (plk1) for the treatment of cancer and their use for the treatment of bacterial infections
TTO:6.1364
| Patent number | Country code | Kind code | Date issued |
US2015368209 | US | A1 | 2015-12-24 |
EP2941428 | EP | A1 | 2015-11-11 |
WO2014106762 | WO | A1 | 2014-07-10 |