Pharmacological stimulation to facilitate and restore standing and walking functions in spinal cord motor disorders
The invention relates to the selective targeting of specific α2 adrenergic receptor subtypes for facilitating and also restoring standing and walking in a subject affected by spinal cord disorders, in particular spinal cord injury. In particular, the improvement of locomotion by targeting specific receptor subtypes can be achieved by stimulation of the α2c receptor subtype using an α2c specific agonist or by blocking the α2a receptor subtype using α2a antagonists. A combination of an α2c agonist and an α2a antagonist is also provided for a synergistic effect. Alternatively, a large α2 agonist can be used in combination with an α2a antagonist to achieve specific stimulation of the α2c receptor. Pharmaceutical compositions, kit-of-parts and therapeutic systems comprising said agonists/antagonists as active agents are objects of the present invention. A robotic interface and epidural electric stimulation can also be used in combination with the compositions of the invention for restoring voluntary control of locomotion.
48698959
Alternative title(s) : (de) Pharmakologische stimulation zur unterstützung und wiederherstellung von steh- und gehfunktionen bei rückenmarkserkrankungen (fr) Stimulation pharmacologique afin de faciliter et restaurer des fonctions pour se tenir debout et marcher dans des troubles de la moelle épinière (en) Pharmacological stimulation to facilitate and restore standing and walking functions in spinal cord disorders
TTO:6.1182
Patent number | Country code | Kind code | Date issued |
US10632105 | US | B2 | 2020-04-28 |
US2016158204 | US | A1 | 2016-06-09 |
WO2015000800 | WO | A1 | 2015-01-08 |
EP2821072 | EP | A1 | 2015-01-07 |