Active Agent-Particle Combination Supporting Bone Regeneration
The invention provides for a bioactive composition comprising solid particles, such as e.g. calcium phosphate particles, loaded with an active agent, preferably an osteoconductive/osteoinductive agent or an anti-resorptive agent like a bisphosphonate. The drug-loaded particles are included into a carrier that is preferably composed of a polymeric matrix, such as for instance a hyaluronic acid-based hydrogel. The composition is particularly useful for the treatment of bone defects, including dental-related pathological conditions, and particularly for bone regeneration/healing. The composition can be applied and/or injected directly in situ to perform its action on the bone defect. A pharmaceutical composition comprising the bioactive composition is also disclosed herein.
52781009
Alternative title(s) : (de) Wirkstoff-partikel-kombination zur unterstützung der knochenregeneration (fr) Combinaison agent actif-particule favorisant la régénération osseuse (en) Active agent-particle combination supporting bone regeneration
TTO:6.1374
Patent number | Country code | Kind code | Date issued |
ES2893354 | ES | T3 | 2022-02-08 |
EP3116555 | EP | B1 | 2021-08-25 |
US2017056559 | US | A1 | 2017-03-02 |
EP3116555 | EP | A1 | 2017-01-18 |
WO2015135822 | WO | A1 | 2015-09-17 |