000227661 001__ 227661
000227661 005__ 20190806111834.0
000227661 0247_ $$2doi$$a10.1111/1755-5922.12238
000227661 022__ $$a1755-5914
000227661 02470 $$2ISI$$a000397576100003
000227661 037__ $$aARTICLE
000227661 245__ $$aPhotodynamic therapy for the treatment of atherosclerotic plaque: Lost in translation?
000227661 269__ $$a2017
000227661 260__ $$bWiley$$c2017$$aHoboken
000227661 300__ $$a14
000227661 336__ $$aReviews
000227661 520__ $$aAcute coronary syndrome is a life-threatening condition of utmost clinical importance, which, despite recent progress in the field, is still associated with high morbidity and mortality. Acute coronary syndrome results from a rupture or erosion of vulnerable atherosclerotic plaque with secondary platelet activation and thrombus formation, which leads to partial or complete luminal obstruction of a coronary artery. During the last decade, scientific evidence demonstrated that when an acute coronary event occurs, several nonculprit plaques are in a vulnerable state. Among the promising approaches, several investigations provided evidence of photodynamic therapy (PDT)-induced stabilization and regression of atherosclerotic plaque. Significant development of PDT strategies improved its therapeutic outcome. This review addresses PDT's pertinence and major problems/challenges toward its translation to a clinical reality.
000227661 6531_ $$aAtherosclerosis
000227661 6531_ $$aLaser
000227661 6531_ $$aPhotodynamic therapy
000227661 6531_ $$aPhotosensitizers
000227661 6531_ $$aRestenosis
000227661 6531_ $$aTheranostic
000227661 700__ $$uUniv & Hosp Fribourg, Dept Med, Cardiol, Fribourg, Switzerland$$aJain, Manish
000227661 700__ $$0246077$$g110512$$aZellweger, Matthieu
000227661 700__ $$0241203$$g106697$$aWagnieres, Georges
000227661 700__ $$0240886$$g106613$$aVan Den Bergh, Hubert
000227661 700__ $$aCook, Stephane$$uUniv & Hosp Fribourg, Dept Med, Cardiol, Fribourg, Switzerland
000227661 700__ $$aGiraud, Marie-Noelle$$uUniv & Hosp Fribourg, Dept Med, Cardiol, Fribourg, Switzerland
000227661 773__ $$j35$$tCardiovascular Therapeutics$$k2
000227661 909CO $$pSB$$preview$$pSTI$$ooai:infoscience.tind.io:227661
000227661 909C0 $$xS14027$$pGPM$$0252512
000227661 909C0 $$0252359$$pGR-VDB
000227661 917Z8 $$x106697
000227661 937__ $$aEPFL-REVIEW-227661
000227661 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000227661 980__ $$aREVIEW