Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control

We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. We show that viral genetic diversity explains 29% of the variation in viral load while host factors explain 8.4%. Using a joint model including both host and viral effects, we estimate a total of 30% heritability, indicating that most of the host effects are reflected in viral sequence variation.


Published in:
PLoS Computational Biology, 13, 2, e1005339
Year:
2017
Publisher:
San Francisco, Public Library of Science
ISSN:
1553-734X
Laboratories:




 Record created 2017-03-27, last modified 2018-09-13

Publisher's version:
Download fulltext
PDF

Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)