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research report
Subtilin Production by Bacillus Subtilis: Stochastic Hybrid Models and Parameter Identification
2006
This paper presents methods for the parameter identification of a model of subtilin production by Bacillus subtilis. Based on a stochastic hybrid model, identification is split in two subproblems: estimation of the genetic network regulating subtilin production from gene expression data, and estimation of population dynamics based on nutrient and population level data. Techniques for identification of switching dynamics from sparse and irregularly sampled observations are developed and applied to simulated data. Numerical results are provided to show the effectiveness of our methods.
Type
research report
Author(s)
Cinquemani, E.
•
Porreca, R.
•
Ferrari-Trecate, G.
•
Lygeros, J.
Date Issued
2006
Peer reviewed
REVIEWED
Written at
OTHER
EPFL units
Available on Infoscience
January 10, 2017
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