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  4. Cervix Cancer Spatial Modelling for Brachytherapy Applicator Analysis
 
journal article

Cervix Cancer Spatial Modelling for Brachytherapy Applicator Analysis

Rogelj, Peter
•
Barakovic, Muhamed  
2015
Informatica - An International Journal of Computing and Informatics

Standard applicators for cervix cancer brachytherapy (BT) do not always enable a sufficient radiation dose coverage of the target structure (HR-CTV). The aim of this study was to develop methodology for building models of the BT target from a cohort of cervix cancer patients, which would enable BT applicator testing. In this paper we propose two model types, a spatial distribution model and a principal component model. Each of them can be built from data of several patients that includes medical images of arbitrary resolution and modality supplemented with delineations of HR-CTV structure, reconstructed applicator structure and eventual organs at risk (OAR) structures. The spatial distribution model is a static model providing probability distribution of the target in the applicator coordinate system, and as such provides information of the target region that applicators must be able to cover. The principal component model provides information of the target spatial variability described by only a few parameters. It can be used to predict specific extreme situations in the scope of sufficient applicator radiation dose coverage in the target structure as well as radiation dose avoidance in OARs. The results are generated 3D images that can be imported into existent BT planning systems for further BT applicator analysis and eventual improvements.

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Type
journal article
Author(s)
Rogelj, Peter
Barakovic, Muhamed  
Date Issued

2015

Published in
Informatica - An International Journal of Computing and Informatics
Volume

39

Issue

3

Start page

261

End page

269

Subjects

cervix cancer

•

spatial distribution

•

PCA

•

BT applicators

Editorial or Peer reviewed

NON-REVIEWED

Written at

OTHER

EPFL units
IEL  
Available on Infoscience
December 12, 2016
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/131906
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