An Evaluation Framework for Lossy Compression of Genome Sequencing Quality Values

This paper provides the specification and an initial validation of an evaluation framework for the comparison of lossy compressors of genome sequencing quality values. The goal is to define reference data, test sets, tools and metrics that shall be used to evaluate the impact of lossy compression of quality values on human genome variant calling. The functionality of the framework is validated referring to two state-of-the-art genomic compressors. This work has been spurred by the current activity within the ISO/IEC SC29/WG11 technical committee (a.k.a. MPEG), which is investigating the possibility of starting a standardization activity for genomic information representation.


Published in:
Proceedings of the Data Compression Conference
Presented at:
IEEE Data Compression Conference 2016, Snowbird, Utah, USA
Year:
2016
Publisher:
New York, Ieee
ISBN:
978-1-5090-1853-6
Keywords:
Laboratories:


Note: The status of this file is: EPFL only


 Record created 2016-12-01, last modified 2018-09-13

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