Use of VacA as a Vaccine Antigen

One of the major toxins secreted by H. pylori is the Vacuolating cytotoxin A (VacA) named after its ability to induce the formation of "vacuole"-like membrane vesicles in the cytoplasm of gastric cells. VacA has been associated with the disruption of mitochondrial functions, stimulation of apoptosis, blockade of T cell proliferation and promotion of regulatory T cells, thereby making it a promising vaccine target. Immunity to bacterial virulence factors is well known to protect humans against bacterial infections; hence, detoxified VacA has been evaluated as a vaccine antigen. Our short review summarizes the pre-clinical and clinical data that have been published on the use of VacA in the development of the H. pylori vaccine.


Published in:
Toxins, 8, 6, 181
Year:
2016
Publisher:
Basel, Mdpi Ag
ISSN:
2072-6651
Keywords:
Laboratories:




 Record created 2016-10-18, last modified 2018-09-13


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