Immunogenic subcellular vesicular particles that can be used to stimulate antigen-specific immune responses in vitro and in vivo are generated from whole cancer cells. The particles retain a broad antigen repertoire similar to that of the parent cells, and can be loaded with disparate adjuvant payloads. These particles may represent a superior alternative to lysate, the standard for primary antigen preparations, in various cancer vaccine applications.
Type
research article
Authors
Cheung, Alexander S.
•
Koshy, Sandeep T.
•
Stafford, Alexander G.
•
•
Mooney, David J.
Publication date
2016
Publisher
Published in
Volume
12
Issue
17
Start page
2321
End page
2333
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
August 30, 2016
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