Sustained Delivery Of Insulin-Like Growth Factor-1/Hepatocyte Growth Factor Promotes Endogenous Cardiac Repair And Regeneration In The Chronic Ischemic Heart
2013
Abstract
The aim of this study was to test the sustained release of insulin-like growth factor-1 (IGF-1) and hepatocyte growth factor (HGF) using an injectable supramolecular hydrogel based on ureido-pyrimidinone (UPy) moieties in order to recruit and activate endogenous porcine cardiac stem/progenitor cells (epCSCs) towards the infarct borderzone leading to increased myocardial repair in a porcine model of chronic myocardial infarction (MI).
Details
Title
Sustained Delivery Of Insulin-Like Growth Factor-1/Hepatocyte Growth Factor Promotes Endogenous Cardiac Repair And Regeneration In The Chronic Ischemic Heart
Author(s)
Koudstaal, Stefan ; Bastings, Maartje ; Ellison, Georgina ; Feyen, Dries ; Waring, Cheryl ; Torella, Daniele ; Meijer, Bert ; Sluijter, Joost ; Nadal-Ginard, Bernardo ; Doevendans, Pieter ; Dankers, Patricia ; Chamuleau, Steven
Published in
Journal of the American College of Cardiology
Volume
61
Issue
10
Pages
E1141
Conference
62nd Annual Scientific Session of the American College of Cardiology, San Francisco, CA, March 9-11, 2013
Date
2013
Laboratories
PBL
Record Appears in
Scientific production and competences > STI - School of Engineering > IMX - Institute of Materials > PBL - Programmable Biomaterials Laboratory
Peer-reviewed publications
Work outside EPFL
Conference Papers
Published
Peer-reviewed publications
Work outside EPFL
Conference Papers
Published
Record creation date
2016-08-30