Hierarchical Formation of Supramolecular Transient Networks in Water: A Modular Injectable Delivery System
2012
Abstract
A modular one-component supramolecular transient network in water, based on poly(ethylene glycol) and end-capped with four-fold hydrogen bonding units, is reported. Due to its nonlinear structural formation, this system allows active proteins to be added to the hydrogel during formation. Once implanted in vivo it releases the protein by erosion of both the protein and polymer via dissolution.
Details
Title
Hierarchical Formation of Supramolecular Transient Networks in Water: A Modular Injectable Delivery System
Author(s)
Dankers, Patricia Y. W. ; Hermans, Thomas M. ; Baughman, Travis W. ; Kamikawa, Yuko ; Kieltyka, Roxanne E. ; Bastings, Maartje ; Janssen, Henk M. ; Sommerdijk, Nico A. J. M. ; Larsen, Antje ; Van Luyn, Marja J. A. ; Bosman, Anton W. ; Popa, Eliane R. ; Fytas, George ; Meijer, E. W.
Published in
Advanced Materials
Volume
24
Issue
20
Pages
2703-2709
Date
2012
Publisher
Wiley-Blackwell
ISSN
0935-9648
Laboratories
PBL
Record Appears in
Scientific production and competences > STI - School of Engineering > IMX - Institute of Materials > PBL - Programmable Biomaterials Laboratory
Peer-reviewed publications
Work outside EPFL
Journal Articles
Published
Peer-reviewed publications
Work outside EPFL
Journal Articles
Published
Record creation date
2016-08-30