Radiative Engineering of NanoAntenna Arrays for Ultra-Sensitive Vibrational Spectroscopy of Proteins

Infrared absorption spectroscopy offers direct access to the vibrational signatures of molecular structure. Although absorption cross sections are nearly 10 orders of magnitude larger than the Raman cross sections, they are small in comparison with those of fluorescent labels. Sensitivity improvements are therefore required in order for the method to be applicable to single molecule/monolayer studies. In this work, we demonstrate a plasmon enhanced vibrational spectroscopy technique which allow for the measurement of molecule specific signatures at the monolayer level. Specifically, we show 4-5 order of magnitude enhancement of the amide-I and II backbone signature of protein monolayers, the signal resulting from only zeptomole quantities of molecules.


Editor(s):
Stockman, MI
Published in:
PLASMONICS: METALLIC NANOSTRUCTURES AND THEIR OPTICAL PROPERTIES VIII, 7757
Presented at:
PLASMONICS: METALLIC NANOSTRUCTURES AND THEIR OPTICAL PROPERTIES VIII, 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
Year:
2010
Publisher:
SPIE-INT SOC OPTICAL ENGINEERING
ISBN:
978-0-8194-8253-2
Keywords:
Note:
Conference on Plasmonics: Metallic Nanostructures and Their Optical Properties VIII, San Diego, CA, AUG 01-05, 2010
Laboratories:




 Record created 2016-08-16, last modified 2018-03-17


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