Integrated nanoplasmonic-nanofluidic biosensors with targeted delivery of analytes

• Published in: APPLIED PHYSICS LETTERS (ISSN: 0003-6951), vol. 96, num. 2, p. article n°021101
• Publication date: 2010

Performances of the biosensors are often limited by the depletion zones created around the sensing area which impede the effective analyte transport. To overcome this limitation, we propose and demonstrate a nanoplasmonic-nanofluidic sensor enabling targeted delivery of analytes to the sensor surface with dramatic improvements in mass transport efficiency. Our sensing platform is based on extraordinary light transmission effect in suspended plasmonic nanoholes. This scheme allows three-dimensional control of the fluidic flow by connecting separate layers of microfluidic channels through plasmonic/nanofluidic holes. To implement the proposed sensor platform, we also introduce a lift-off free nanofabrication method.

Keywords: bioMEMS ; biosensors ; microchannel flow ; nanobiotechnology ; nanofluidics ; nanosensors ; Plasmonics

Reference

• EPFL-ARTICLE-220822
• doi:10.1063/1.3290633

Record created on 2016-08-16, modified on 2017-05-10