Recent neuroscience research emphasizes the embodied origins of the experience of the self. This chapter shows that further advances in the understanding of the phenomenon of VR-induced presence might be achieved in connection with advances in the understanding of the brain mechanisms of bodily self-consciousness. By reviewing the neural mechanisms that make the virtual reality experience possible and the neurocognitive models of bodily self-consciousness, we highlight how the development of applied human computer confluence technologies and the fundamental scientific investigation of bodily self-consciousness benefit from each other in a symbiotic manner.