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research article
Synthesis of Diversely Functionalized Oxindoles Enabled by Migratory Insertion of Isocyanide to a Transient σ-Alkylpalladium(II) Complex
Palladium-catalyzed intramolecular carbopalladation of N-aryl acrylamides followed by migratory insertion of an isocyanide-coordinated C(sp3)-Pd intermediate afforded an alkylimidoyl-Pd(II) complex, which can be intercepted by a nucleophile, including heteroarenes. In addition to amides, the alkylimidoyl-Pd(II) complex was successfully converted into esters, ketones, and bis-heterocyclic compounds. An unprecedented palladium-catalyzed enantioselective domino process involving isocyanide was also documented.
Type
research article
Web of Science ID
WOS:000383372700047
Authors
Publication date
2016
Publisher
Published in
Volume
55
Issue
33
Start page
9714
End page
9718
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
August 5, 2016
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