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  4. TIE-2-expressing monocytes are lymphangiogenic and associate specifically with lymphatics of human breast cancer
 
research article

TIE-2-expressing monocytes are lymphangiogenic and associate specifically with lymphatics of human breast cancer

Bron, Sylvian
•
Henry, Luc
•
Faes-Van'T Hull, Eveline
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2016
Oncoimmunology

In experimental mouse models of cancer, increasingly compelling evidence point toward a contribution of tumor associated macrophages (TAM) to tumor lymphangiogenesis. Corresponding experimental observations in human cancer remain scarce although lymphatic metastasis is widely recognized as a predominant route for tumor spread. We previously showed that, in malignant tumors of untreated breast cancer (BC) patients, TIE-2-expressing monocytes (TEM) are highly proangiogenic immunosuppressive cells and that TIE-2 and VEGFR signaling pathways drive TEM immunosuppressive function. We report here that, in human BC, TEM express the canonical lymphatic markers LYVE-1, Podoplanin, VEGFR-3 and PROX-1. Critically, both TEM acquisition of lymphatic markers and insertion into lymphatic vessels were observed in tumors but not in adjacent non-neoplastic tissues, suggesting that the tumor microenvironment shapes both TEM phenotype and spatial distribution. We assessed the lymphangiogenic activity of TEM isolated from dissociated primary breast tumors in vitro and in vivo using endothelial cells (EC) sprouting assay and corneal vascularization assay, respectively. We show that, in addition to their known hemangiogenic function, TEM isolated from breast tumor display a lymphangiogenic activity. Importantly, TIE-2 and VEGFR pathways display variable contributions to TEM angiogenic and lymphangiogenic activities across BC patients; however, combination of TIE-2 and VEGFR kinase inhibitors abrogated these activities and overcame inter-patient variability. These results highlight the direct contribution of tumor TEM to the breast tumor lymphatic network and suggest a combined use of TIE-2 and VEGFR kinase inhibitors as a therapeutic approach to block hem-and lymphangiogenesis in BC.

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Type
research article
DOI
10.1080/2162402X.2015.1073882
Web of Science ID

WOS:000373385000043

Author(s)
Bron, Sylvian
Henry, Luc
Faes-Van'T Hull, Eveline
Turrini, Riccardo
Vanhecke, Dominique
Guex, Nicolas
Ifticene-Treboux, Assia
Iancu, Emanuela Marina
Semilietof, Aikaterini
Rufer, Nathalie
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Date Issued

2016

Publisher

Taylor & Francis Inc

Published in
Oncoimmunology
Volume

5

Issue

2

Article Number

e1073882

Subjects

Angiogenesis

•

breast cancer

•

lymphatics

•

TIE-2expressing monocytes

•

tumor microenvironment

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
ISIC  
Available on Infoscience
July 19, 2016
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/128010
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